Zhefeng Guo Laboratory

Just published online: Alzheimer’s A42 and A40 form mixed oligomers with direct molecular interactions, by Lei Gu and Zhefeng Guo. https://doi.org/10.1016/j.bbrc.2020.11.092

Just published online: Distinguishing the effect on the rate and yield of A42 aggregation by green tea polyphenol EGCG, by Giovanna Park, Christine Xue, Hongsu Wang, and Zhefeng Guo. http://doi.org/10.1021/acsomega.0c02063

Amy Zhang, an undergraduate student majoring in Neuroscience, just received a Life Science Dean's Award for Neuroscience Research for the 2020-21 academic year. Amy has been in the Guo lab since the fall quarter of 2019. She has been working on A aggregation involved in Alzheimer's disease and has been doing a terrific job! This award is a testament of her dedication and excellence. Congratulations!

Just published: Polymorphic A42 fibrils adopt similar secondary structure but differ in cross-strand side chain stacking interactions within the same -sheet

Just published online: Spin label scanning reveals likely locations of -strands in the amyloid fibrils of the Ure2 prion domain